Which receptor on phagocytes recognizes C3b to promote phagocytosis?

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Multiple Choice

Which receptor on phagocytes recognizes C3b to promote phagocytosis?

Explanation:
Opsonization by C3b enhances phagocytosis through CR1 (CD35) on phagocytes. When C3b is deposited on a microbe, CR1 binds this C3b (and also C4b), signaling the phagocyte to engulf the opsonized particle and form a phagosome. This receptor-ligand interaction is the key link between complement tagging and efficient internalization. Other receptors handle different targets: Fc gamma receptors recognize antibody-coated particles, CR3 binds iC3b rather than C3b, and CD64 is an Fc receptor for IgG. CD40 is a co-stimulatory molecule, not a phagocytic receptor for C3b.

Opsonization by C3b enhances phagocytosis through CR1 (CD35) on phagocytes. When C3b is deposited on a microbe, CR1 binds this C3b (and also C4b), signaling the phagocyte to engulf the opsonized particle and form a phagosome. This receptor-ligand interaction is the key link between complement tagging and efficient internalization. Other receptors handle different targets: Fc gamma receptors recognize antibody-coated particles, CR3 binds iC3b rather than C3b, and CD64 is an Fc receptor for IgG. CD40 is a co-stimulatory molecule, not a phagocytic receptor for C3b.

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