Which combination of markers is characteristic of helper T cells in flow cytometry?

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Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

Which combination of markers is characteristic of helper T cells in flow cytometry?

Explanation:
Helper T cells are identified by marker combinations that reflect both T-cell lineage and function. All mature T cells carry CD3, and the helper subset specifically expresses CD4. So cells that are CD3+ and CD4+ correspond to helper T cells. Other marker pairs point to different immune cells: CD3 with CD8 marks cytotoxic T cells; CD19 and CD20 indicate B cells; and CD56 with CD16 marks NK cells.

Helper T cells are identified by marker combinations that reflect both T-cell lineage and function. All mature T cells carry CD3, and the helper subset specifically expresses CD4. So cells that are CD3+ and CD4+ correspond to helper T cells. Other marker pairs point to different immune cells: CD3 with CD8 marks cytotoxic T cells; CD19 and CD20 indicate B cells; and CD56 with CD16 marks NK cells.

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