Which antibody isotype is predominant in secretions and is produced as a dimer?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

Which antibody isotype is predominant in secretions and is produced as a dimer?

Explanation:
Mucosal immunity relies on secretory IgA, produced as a dimer. Two IgA monomers are linked by a J chain and then transported across the epithelium by the polymeric Ig receptor, acquiring a secretory component to form secretory IgA. This form is the main antibody in secretions like saliva, tears, and mucus, and it neutralizes pathogens in the lumen while remaining relatively noninflammatory. In contrast, IgG is the main systemic antibody, IgM is produced as a pentamer, and IgE mediates allergic and parasitic responses. Thus the antibody isotype predominant in secretions and produced as a dimer is IgA.

Mucosal immunity relies on secretory IgA, produced as a dimer. Two IgA monomers are linked by a J chain and then transported across the epithelium by the polymeric Ig receptor, acquiring a secretory component to form secretory IgA. This form is the main antibody in secretions like saliva, tears, and mucus, and it neutralizes pathogens in the lumen while remaining relatively noninflammatory. In contrast, IgG is the main systemic antibody, IgM is produced as a pentamer, and IgE mediates allergic and parasitic responses. Thus the antibody isotype predominant in secretions and produced as a dimer is IgA.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy