Which antibody binds to mast cells?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

Which antibody binds to mast cells?

Explanation:
Mast cells are primed to respond to allergens when a specific antibody class binds to their surface via a high‑affinity receptor. IgE binds tightly to the FcεRI receptor on mast cells (and basophils), effectively coating the cell with IgE. When the same allergen is encountered and cross‑links these bound IgE molecules, the mast cell degranulates, releasing histamine and other mediators that drive allergic symptoms. The other antibody classes—IgA, IgG, and IgM—don’t bind mast cells in this way to trigger degranulation; they have different roles and interact with different receptors, such as Fcγ receptors for IgG, Fcα receptors for IgA, and complement activation for IgM.

Mast cells are primed to respond to allergens when a specific antibody class binds to their surface via a high‑affinity receptor. IgE binds tightly to the FcεRI receptor on mast cells (and basophils), effectively coating the cell with IgE. When the same allergen is encountered and cross‑links these bound IgE molecules, the mast cell degranulates, releasing histamine and other mediators that drive allergic symptoms. The other antibody classes—IgA, IgG, and IgM—don’t bind mast cells in this way to trigger degranulation; they have different roles and interact with different receptors, such as Fcγ receptors for IgG, Fcα receptors for IgA, and complement activation for IgM.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy