What is the function of IL-3?

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Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

What is the function of IL-3?

Explanation:
IL-3 is a hematopoietic growth factor that acts on multipotent bone marrow stem cells to promote their survival, proliferation, and differentiation into multiple blood cell lineages. It’s produced by activated T cells (and mast cells) and signals through a receptor sharing the beta common chain with GM-CSF and IL-5, enabling broad support of early progenitors. This makes its primary function the growth and differentiation of bone marrow stem cells. Fever is driven by IL-1 and TNF; Ig class switching is promoted mainly by IL-4; erythropoiesis is driven by erythropoietin.

IL-3 is a hematopoietic growth factor that acts on multipotent bone marrow stem cells to promote their survival, proliferation, and differentiation into multiple blood cell lineages. It’s produced by activated T cells (and mast cells) and signals through a receptor sharing the beta common chain with GM-CSF and IL-5, enabling broad support of early progenitors. This makes its primary function the growth and differentiation of bone marrow stem cells. Fever is driven by IL-1 and TNF; Ig class switching is promoted mainly by IL-4; erythropoiesis is driven by erythropoietin.

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