The J chain in immunoglobulins is primarily responsible for which function?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

The J chain in immunoglobulins is primarily responsible for which function?

Explanation:
The joining (J) chain’s main role is to link antibody subunits to form polymeric immunoglobulins, specifically dimers of IgA and pentamers of IgM. This polymerization enables these antibodies to be secreted across mucosal surfaces and to function effectively in mucosal immunity. It’s not involved in triggering isotype switching (that’s driven by cytokines and activation-induced cytidine deaminase), nor does it stabilize IgG (IgG is a monomer), and it doesn’t directly enhance antigen affinity (affinity maturation comes from somatic hypermutation and selection).

The joining (J) chain’s main role is to link antibody subunits to form polymeric immunoglobulins, specifically dimers of IgA and pentamers of IgM. This polymerization enables these antibodies to be secreted across mucosal surfaces and to function effectively in mucosal immunity. It’s not involved in triggering isotype switching (that’s driven by cytokines and activation-induced cytidine deaminase), nor does it stabilize IgG (IgG is a monomer), and it doesn’t directly enhance antigen affinity (affinity maturation comes from somatic hypermutation and selection).

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy