Pemphigus vulgaris demonstrates which hypersensitivity type?

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Multiple Choice

Pemphigus vulgaris demonstrates which hypersensitivity type?

Explanation:
Pemphigus vulgaris is driven by IgG autoantibodies directed against desmoglein proteins in desmosomes between keratinocytes. When these antibodies bind, they disrupt cell–cell adhesion in the epidermis and mucous membranes, causing acantholysis and blister formation. This is characteristic of antibody-mediated damage to cell surface antigens, i.e., Type II hypersensitivity. Type I is IgE-mediated immediate allergy, Type III involves immune complex deposition, and Type IV is T-cell–mediated delayed hypersensitivity, none of which describe the primary mechanism in pemphigus vulgaris.

Pemphigus vulgaris is driven by IgG autoantibodies directed against desmoglein proteins in desmosomes between keratinocytes. When these antibodies bind, they disrupt cell–cell adhesion in the epidermis and mucous membranes, causing acantholysis and blister formation. This is characteristic of antibody-mediated damage to cell surface antigens, i.e., Type II hypersensitivity.

Type I is IgE-mediated immediate allergy, Type III involves immune complex deposition, and Type IV is T-cell–mediated delayed hypersensitivity, none of which describe the primary mechanism in pemphigus vulgaris.

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