In Hyper-IgM syndrome, which immunoglobulin is typically elevated?

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Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

In Hyper-IgM syndrome, which immunoglobulin is typically elevated?

Explanation:
The main concept is defective class-switch recombination. In Hyper-IgM syndrome, B cells cannot switch from producing IgM to other isotypes (IgG, IgA, IgE) due to impaired CD40-CD40L signaling or related CSR defects. Because switching is blocked, IgM remains the predominant antibody produced and is elevated, while the other isotypes are low. So the immunoglobulin typically elevated is IgM.

The main concept is defective class-switch recombination. In Hyper-IgM syndrome, B cells cannot switch from producing IgM to other isotypes (IgG, IgA, IgE) due to impaired CD40-CD40L signaling or related CSR defects. Because switching is blocked, IgM remains the predominant antibody produced and is elevated, while the other isotypes are low. So the immunoglobulin typically elevated is IgM.

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