In flow cytometry, which markers identify helper T cells?

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Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

In flow cytometry, which markers identify helper T cells?

Explanation:
In flow cytometry, helper T cells are defined by being CD4-positive T cells that also express the T cell marker CD3. CD3 marks the T cell receptor complex, so all T cells are CD3+, and the helper subset is specifically CD4+. Therefore, identifying cells as CD3+ and CD4+ singles out the helper T cells. The other marker combinations point to other lineages or subsets: CD3 with CD8 marks cytotoxic T cells; CD19 and CD20 mark B cells; CD8 with CD56 would not selectively define helpers and could include other populations.

In flow cytometry, helper T cells are defined by being CD4-positive T cells that also express the T cell marker CD3. CD3 marks the T cell receptor complex, so all T cells are CD3+, and the helper subset is specifically CD4+. Therefore, identifying cells as CD3+ and CD4+ singles out the helper T cells. The other marker combinations point to other lineages or subsets: CD3 with CD8 marks cytotoxic T cells; CD19 and CD20 mark B cells; CD8 with CD56 would not selectively define helpers and could include other populations.

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