In flow cytometry, which marker is used to identify helper T cells?

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Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

In flow cytometry, which marker is used to identify helper T cells?

Explanation:
In flow cytometry, identifying helper T cells relies on a specific surface protein they consistently express. Helper T cells are characterized by CD4 on their surface, which serves as the co-receptor for MHC class II and marks this subset. This is what lets you distinguish them from other lymphocytes: cytotoxic T cells carry CD8, B cells carry CD19, and natural killer cells carry CD56. So, to identify helper T cells in a flow cytometry panel, you look for CD4 expression (often within the gate for CD3+ T cells). This marker is also clinically relevant because HIV targets CD4+ T cells, underscoring why distinguishing this population matters.

In flow cytometry, identifying helper T cells relies on a specific surface protein they consistently express. Helper T cells are characterized by CD4 on their surface, which serves as the co-receptor for MHC class II and marks this subset. This is what lets you distinguish them from other lymphocytes: cytotoxic T cells carry CD8, B cells carry CD19, and natural killer cells carry CD56. So, to identify helper T cells in a flow cytometry panel, you look for CD4 expression (often within the gate for CD3+ T cells). This marker is also clinically relevant because HIV targets CD4+ T cells, underscoring why distinguishing this population matters.

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