Goodpasture syndrome is associated with autoantibodies against which structure?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the NBME Immunology Test. Study with flashcards and multiple choice questions, each question includes hints and explanations. Prepare to excel!

Multiple Choice

Goodpasture syndrome is associated with autoantibodies against which structure?

Explanation:
Goodpasture syndrome centers on autoantibodies that target a component of basement membranes, specifically type IV collagen. The glomerular and alveolar basement membranes are rich in type IV collagen, and autoantibodies against the NC1 domain of the alpha-3 chain of this collagen disrupt this network. This causes inflammation in the kidneys and lungs, producing rapidly progressive glomerulonephritis and pulmonary hemorrhage with linear IgG (and C3) deposition along basement membranes on immunofluorescence. Other collagens (types I, II, III) are not the major constituents of these basement membranes, so antibodies against them don’t explain Goodpasture’s lesions.

Goodpasture syndrome centers on autoantibodies that target a component of basement membranes, specifically type IV collagen. The glomerular and alveolar basement membranes are rich in type IV collagen, and autoantibodies against the NC1 domain of the alpha-3 chain of this collagen disrupt this network. This causes inflammation in the kidneys and lungs, producing rapidly progressive glomerulonephritis and pulmonary hemorrhage with linear IgG (and C3) deposition along basement membranes on immunofluorescence. Other collagens (types I, II, III) are not the major constituents of these basement membranes, so antibodies against them don’t explain Goodpasture’s lesions.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy